Left ventricular hypertrabeculation - an unanswered question

Abstract Funding Acknowledgements Type of funding sources: Other. Main source(s): Supported by the ÚNKP-19-3-II New National Excellence Program Ministry for Innovation and Technology Left ventricular (LV) hypertrabeculation (H-TRAB) is a morphological description when LV highly trabeculated, but it remains below diagnostic criterion noncompaction cardiomyopathy (NCMP). Although, frequent finding on cardiac MRI scans its prognostic relevance controversial. In this study, we aimed to describe functional feature-tracking strain values healthy subjects with H-TRAB decide whether normal variant or an NCMP-like pattern. We included 189 adult participants good ejection fraction (EF), without co-morbidities. 63 them had morphology (H-TRAB, age: 37.1 ± 14.4 years; EF: 66.4 5.1%), patients were diagnosed NCMP (age: 36.3 14.0 years, 65.8 5.5%) remaining people controls (38.3 69.0 4.9%). MR examinations performed 1,5T Philips Achieva Siemens Aera devices. The Medis Suite software was used post-processing analysis, MedCalc statistics, p < 0.05 considered statistically significant. No significant differences found between parameters groups. However, EF decreased, end-diastolic (EDVi), end-systolic volume (ESVi), myocardial mass (LV-massi), trabeculated muscle (LV-trabi) increased in both groups compared (H-TRAB vs. control: 6.4 5.4 5.0%, EDVi: 74.4 14.3 69.7 12.8 ml/m2, ESVi: 25.1 6.7 21.7 5.8 LV-massi: 77.0 15.1 71.2 12.3 g/m2, LV-trabi: 25.0 5.1 20.1 4.0 g/m2; 5.5 77.8 15.0 26.7 7.9 76.8 18.0 25.9 7.5 ? 0.05). global circumferential (GCS) differed significantly these groups: absolute value lowest highest control group (NCMP -30.2% -34.3% -35.9%; Similar results comparison mean segmental apical-, mid- basal-parts three patients, followed H-TRAB, group. These suggest that population are more similar than controls. Further studies necessary determine pathological implications consequences morphology.